ReplicateBE.jl Documentation
ReplicateBE is a Julia package providing mixed model solution for replicate designed bioequivalence study. This can be used to obtained results with methods C (random effects with interaction), given by the EMA in Annex I. Statistical model formed with accordance FDA Guidance for Industry: Statistical Approaches to Establishing Bioequivalence, APPENDIX F.
Installation
Install:
using Pkg; Pkg.add("ReplicateBE")or:
using Pkg; Pkg.clone("https://github.com/PharmCat/ReplicateBE.jl.git")Contents
- Bioequivalence example
- Random dataset generation
- Simulation
- Simple (modifying) syntax
- Simple (non-modifying) syntax
- Random dataset
- Simulation
- Introduction
- Materials and Methods
- Validation
- Installation and using
- Results
- Discussion
- Development and version description
- Acknowledgments
- Literature Cited
- Validation
- 24 subjects, balanced
- 48 subjects, unbalanced, 20 dropped observations
- 36 subject unbalanced dataset
- 24 subject, №8 repeat
- 128 subject unbalanced dataset
- 512 subject unbalanced dataset
- Special cases
- Simulation
- Structures
- ReplicateBE.ContrastTable
- ReplicateBE.Design
- ReplicateBE.EffectTable
- ReplicateBE.EstimateTable
- ReplicateBE.RandRBEDS
- API
- ReplicateBE.rbe
- ReplicateBE.rbe!
- StatsBase.coef
- StatsBase.confint
- StatsBase.dof
- StatsBase.stderror
- ReplicateBE.coefnum
- ReplicateBE.contrast
- ReplicateBE.design
- ReplicateBE.estimate
- ReplicateBE.fixed
- ReplicateBE.optstat
- ReplicateBE.randrbeds
- ReplicateBE.randrbetask
- ReplicateBE.reml2
- ReplicateBE.simulation
- ReplicateBE.theta
- ReplicateBE.typeiii