ClinicalTrialUtilities

Clinical trial related calculation: power and sample size calculation, randomization.

Description

The package is designed to perform sample size calculations for clinical trials.

Installation

using Pkg; Pkg.add("ClinicalTrialUtilities");

Note

Further development of NCA PK/PD will be based on MetidaNCA.jl package.

All NCA PK/PD functions moved to MetidaNCA.

Descriptive statistics moved to MetidaStats.

Confidence intervals moved to MetidaFreq.

Simulations removed.

Note

NB! Hypothesis types:

When ctpower/ctsamplen used:

• :ea - Equality: two-sided hypothesis;
• :ei - Equivalencens: two one-sided hypothesis;
• :ns - Non-Inferiority / Superiority: one-sided hypothesis, for some cases you should use two-sided hypothesis for Non-Inferiority/Superiority, you can use alpha/2 for this;

Contents

• SampleSize
• • Introduction
  • • Hypothesis
    • • Equality
      • Equivalence | Bioequivalence
      • Non-inferiority | Superiority
    • ctsamplen
    • besamplen
  • See also
  • • ctask
• Power
• • • ctpower
    • bepower
• Randomization
• • • randomseq
    • randomtable
• Utilities
• • • cvfromci
    • cvfromsd
    • cvfromvar
    • sdfromcv
    • varfromcv
    • pooledcv
• Examples
• • Sample size
  • • Equivalence for two means
    • One proportion equality
    • Odd ratio non-inferiority
    • Odd ratio equality
    • Bioequivalence
  • Power
  • • Equality for one mean
    • Bioequivalence
  • Utilities
  • • CV from CI
    • Polled CV
• References
• • • Sample size / power
    • Confidence intervals
    • R packages

Copyrights

Clinical Trial Utilities

Copyright © 2019 Vladimir Arnautov aka PharmCat <mail@pharmcat.net>

If you want to check and get R code for power/sample size estimation, you can find examples here: http://powerandsamplesize.com/Calculators/