ClinicalTrialUtilities

Clinical trial related calculation: power and sample size calculation, randomization.

Description

The package is designed to perform calculations related to the planning of clinical trials.

Installation

using Pkg; Pkg.add("ClinicalTrialUtilities");

Pharmacodynamics

Further development of NCA PK/PD will be based on MetidaNCA.jl package.

All NCA PK/PD functions moved to MetidaNCA.

Descriptive statistics moved to MetidaStats.

Confidence intervals moved to MetidaFreq.

Simulations removed.

Note

NB! Hypothesis types:

When ctpower/ctsamplen used:

• :ea - Equality: two-sided hypothesis;
• :ei - Equivalencens: two one-sided hypothesis;
• :ns - Non-Inferiority / Superiority: one-sided hypothesis, for some cases you should use two-sided hypothesis for Non-Inferiority/Superiority, you can use alpha/2 for this;

Invalidated version v0.3.0 (removed from release page)

Wrong Equivalence Hypothesis alpha level! Use 0.2.7, 0.3.1 version or higher.

Contents

• SampleSize
• Introduction
• Hypothesis
• Equality
• Equivalence | Bioequivalence
• Non-inferiority | Superiority
• ctsamplen
• besamplen
• Power
• ctpower
• bepower
• Randomization
• randomseq
• randomtable
• Utilities
• cvfromci
• cvfromvar
• pooledcv
• Examples
• Sample size
• Equivalence for two means
• One proportion equality
• Odd ratio non-inferiority
• Odd ratio equality
• Bioequivalence
• Power
• Equality for one mean
• Bioequivalence
• Utilities
• CV from CI
• Polled CV
• Export
• htmlexport
• DataFrame
• References
• Sample size / power
• Confidence intervals
• R packages

Copyrights

Clinical Trial Utilities

Copyright © 2019 Vladimir Arnautov aka PharmCat <mail@pharmcat.net>

If you want to check and get R code for power/sample size estimation, you can find examples here: http://powerandsamplesize.com/Calculators/