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Details

Calculation steps for PK NCA

Step 1

Filter all values before dose time and NaN or missing values after last measurable concentration. If TAU set, calculate start and end timepoints for AUCtau.

Step 2

Cmax, Tmax calculation. Interpolate NaN and missing values.

Note

If more than one maximum - only first observation used for define Tmax.

Step 3

Exclude interpolated points from calculation (add to excltime). Elimination parameters calculation. Find last concentration > 0 and time for last concentration > 0.

Note

If kelstart or kelend in excltime then kelauto set to true.

Note

If kelauto is true than range of observations for elimination will start from Tmax if administration set as iv, and from next observation after Tmax in other cases.

Step 4

Shift all time values by dose time.

Step 5

Calculate dose concentration (Cdose).

Note

If there is no concentration for dosing time:

  • If administration set as iv if 1st observation > than 2nd and both > 0 - Dose concentration is log-extrapolated, else set as 1st observation.
  • If administration not iv, than if Tau used Dose concentration set as minimal concentration, in other case set as 0.

Step 6

Calculate areas.

Note

If AUClast is 0, than AUClast, AUMClast and AUCall set as NaN, so other dependent parameters is NaN too.

Step 7

Calculate steady-state parameters.

Note

If end of tau interval lies between two observation, than interpolation used to compute Ctau and partial AUCs; intpm keyword used to define interpolation method. If end of tau interval lies after all observation, than extrapolation used to compute Ctau and partial AUCs. Extrapolation based on using elimination parameters.

Unitful details

Warning

Unitful.jl MetidaNCA can work with Unitful.jl. There is no guarantee that all functions will work without errors. All validation procedures with Unitful should be done manually before use.

Warning

Dose and time settings If you are using Unitful, check dositime settings: DoseTime(dose = 100u"mg", time = 0u"hr"). For properly results all values should have units (including time and concentration data in data table).